I have a license in my home state. I was wondering if the big trucking companies do a 50 state mvr check or is it just the state that you live in?

It's my experience that companies ask for all states a driver's held a license from. BOL

As long as you list the DL you had in another state, yes. Sometimes the wording is awkward and only asks for CDLs though...

Be honest if you have nothing to hide. You would hate to forget something on the application and then something happen thats not your fault ( someone rear-end you), and when something happens you will be looked at with a fine tooth comb.

that is very true cause that would open up all types of legal trouble.