The tourette's is really going to be a tough one and will most likely come down to the discretion of the doctor who does your physical each time.
They could easily disqualify you under:
Quote:
b)(9) Has no mental, nervous, organic, or functional disease or psychiatric disorder likely to interfere with his/her ability to drive a commercial motor vehicle safely;
Your first stop really should be your doctor and talk to him/her about this and what you are wanting to do. Then if you get a green light there I suggest finding a doctor or clinic that does DOT physicals and go have one done and see what they say.